University of California San Francisco

Publications

  1. Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
    2024 | PubMed
  2. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    2024 | PubMed
  3. Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore.
    2024 | PubMed
  4. Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    2024 | PubMed
  5. Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology.
    2024 | PubMed
  6. Free energy calculations for membrane morphological transformations and insights to physical biology and oncology.
    2024 | PubMed
  7. Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry.
    2024 | PubMed
  8. Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.
    2024 | PubMed
  9. Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.
    2024 | PubMed
  10. The microenvironment dictates glycocalyx construction and immune surveillance.
    2023 | PubMed
  11. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
    2023 | PubMed
  12. Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.
    2023 | PubMed
  13. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
    2023 | PubMed
  14. Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.
    2023 | PubMed
  15. Stiff matrix induces exosome secretion to promote tumour growth.
    2023 | PubMed
  16. Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature.
    2023 | PubMed
  17. Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression.
    2023 | PubMed
  18. Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality.
    2022 | PubMed
  19. Mechanosensitive Steroid Hormone Signaling and Cell Fate.
    2022 | PubMed
  20. Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.
    2022 | PubMed
  21. ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
    2022 | PubMed
  22. Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.
    2022 | PubMed
  23. Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.
    2022 | PubMed
  24. NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
    2021 | PubMed
  25. Mechanobiology: forcing the second act.
    2021 | PubMed
  26. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.
    2021 | PubMed
  27. Tissue mechanics in stem cell fate, development, and cancer.
    2021 | PubMed
  28. EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.
    2021 | PubMed
  29. Adhesion-mediated mechanosignaling forces mitohormesis.
    2021 | PubMed
  30. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
    2021 | PubMed
  31. Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.
    2021 | PubMed
  32. Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.
    2021 | PubMed
  33. Leveraging microenvironmental synthetic lethalities to treat cancer.
    2021 | PubMed
  34. Membrane Tension Locks In Pluripotency.
    2021 | PubMed
  35. Derivation of a nuclear heterogeneity image index to grade DCIS.
    2020 | PubMed
  36. Proteoglycans as Mediators of Cancer Tissue Mechanics.
    2020 | PubMed
  37. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
    2020 | PubMed
  38. Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.
    2020 | PubMed
  39. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
    2020 | PubMed
  40. Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.
    2020 | PubMed
  41. In Memoriam - Zena Werb 1945-2020.
    2020 | PubMed
  42. Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.
    2020 | PubMed
  43. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
    2020 | PubMed
  44. Zena Werb 1945-2020.
    2020 | PubMed
  45. Fibrosis and cancer: A strained relationship.
    2020 | PubMed
  46. Tension in tumour cells keeps metabolism high.
    2020 | PubMed
  47. A framework for advancing our understanding of cancer-associated fibroblasts.
    2020 | PubMed
  48. Don't sugarcoat it: How glycocalyx composition influences cancer progression.
    2020 | PubMed
  49. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.
    2019 | PubMed
  50. Controlled modelling of human epiblast and amnion development using stem cells.
    2019 | PubMed
  51. Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.
    2019 | PubMed
  52. Tissue mechanics, an important regulator of development and disease.
    2019 | PubMed
  53. The Extracellular Matrix Modulates the Metastatic Journey.
    2019 | PubMed
  54. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.
    2018 | PubMed
  55. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.
    2018 | PubMed
  56. Modeling Tissue Polarity in Context.
    2018 | PubMed
  57. Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.
    2018 | PubMed
  58. Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma.
    2018 | PubMed
  59. The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.
    2018 | PubMed
  60. New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
    2018 | PubMed
  61. Feeling Stress: The Mechanics of Cancer Progression and Aggression.
    2018 | PubMed
  62. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.
    2018 | PubMed
  63. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.
    2018 | PubMed
  64. Excess area dependent scaling behavior of nano-sized membrane tethers.
    2018 | PubMed
  65. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.
    2017 | PubMed
  66. Tissue Force Programs Cell Fate and Tumor Aggression.
    2017 | PubMed
  67. α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.
    2017 | PubMed
  68. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.
    2017 | PubMed
  69. Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.
    2017 | PubMed
  70. Cell and tissue mechanics: the new cell biology frontier.
    2017 | PubMed
  71. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.
    2017 | PubMed
  72. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.
    2017 | PubMed
  73. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.
    2017 | PubMed
  74. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.
    2017 | PubMed
  75. Tissue mechanics regulate brain development, homeostasis and disease.
    2017 | PubMed
  76. Force-dependent breaching of the basement membrane.
    2016 | PubMed
  77. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.
    2016 | PubMed
  78. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer.
    2016 | PubMed
  79. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.
    2016 | PubMed
  80. Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.
    2016 | PubMed
  81. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease.
    2016 | PubMed
  82. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.
    2016 | PubMed
  83. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.
    2016 | PubMed
  84. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.
    2016 | PubMed
  85. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes.
    2016 | PubMed
  86. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
    2016 | PubMed
  87. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
    2016 | PubMed
  88. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.
    2016 | PubMed
  89. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.
    2016 | PubMed
  90. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
    2015 | PubMed
  91. Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells.
    2015 | PubMed
  92. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.
    2015 | PubMed
  93. Monitoring developmental force distributions in reconstituted embryonic epithelia.
    2015 | PubMed
  94. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.
    2015 | PubMed
  95. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.
    2015 | PubMed
  96. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.
    2015 | PubMed
  97. Tumor mechanics and metabolic dysfunction.
    2014 | PubMed
  98. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.
    2014 | PubMed
  99. The extracellular matrix modulates the hallmarks of cancer.
    2014 | PubMed
  100. Extracellular matrix assembly: a multiscale deconstruction.
    2014 | PubMed
  101. The microenvironment matters.
    2014 | PubMed
  102. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.
    2014 | PubMed
  103. Multicellular architecture of malignant breast epithelia influences mechanics.
    2014 | PubMed
  104. The cancer glycocalyx mechanically primes integrin-mediated growth and survival.
    2014 | PubMed
  105. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.
    2014 | PubMed
  106. Understanding tissue context influences on intratumour heterogeneity.
    2014 | PubMed
  107. Deconstructing signaling in three dimensions.
    2014 | PubMed
  108. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
    2014 | PubMed
  109. Rapid disorganization of mechanically interacting systems of mammary acini.
    2013 | PubMed
  110. Cell biology. Strength under tension.
    2013 | PubMed
  111. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.
    2013 | PubMed
  112. Collagen architecture in pregnancy-induced protection from breast cancer.
    2013 | PubMed
  113. Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.
    2013 | PubMed
  114. YAP forces fibroblasts to feel the tension.
    2013 | PubMed
  115. MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.
    2013 | PubMed
  116. A physical sciences network characterization of non-tumorigenic and metastatic cells.
    2013 | PubMed
  117. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
    2012 | PubMed
  118. Scanning angle interference microscopy reveals cell dynamics at the nanoscale.
    2012 | PubMed
  119. Morphogenesis: Laying down the tracks.
    2012 | PubMed
  120. The extracellular matrix: a dynamic niche in cancer progression.
    2012 | PubMed
  121. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.
    2012 | PubMed
  122. Extracellular matrix degradation and remodeling in development and disease.
    2011 | PubMed
  123. In situ force mapping of mammary gland transformation.
    2011 | PubMed
  124. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
    2011 | PubMed
  125. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick.
    2011 | PubMed
  126. Balancing forces: architectural control of mechanotransduction.
    2011 | PubMed
  127. Tumor microenvironment and progression.
    2011 | PubMed
  128. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties.
    2011 | PubMed
  129. The extracellular matrix at a glance.
    2010 | PubMed
  130. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis.
    2010 | PubMed
  131. Forcing form and function: biomechanical regulation of tumor evolution.
    2010 | PubMed
  132. Dynamic interplay between the collagen scaffold and tumor evolution.
    2010 | PubMed
  133. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
    2010 | PubMed
  134. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
    2010 | PubMed
  135. Biophysics. Enforcing order on signaling.
    2010 | PubMed
  136. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.
    2009 | PubMed
  137. Matrix crosslinking forces tumor progression by enhancing integrin signaling.
    2009 | PubMed
  138. Mechanics, malignancy, and metastasis: the force journey of a tumor cell.
    2009 | PubMed
  139. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.
    2009 | PubMed
  140. The tissue diagnostic instrument.
    2009 | PubMed
  141. Multiscale modeling of form and function.
    2009 | PubMed
  142. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
    2009 | PubMed
  143. A tense situation: forcing tumour progression.
    2009 | PubMed
  144. Biomechanical regulation of cell orientation and fate.
    2008 | PubMed
  145. Three-dimensional context regulation of metastasis.
    2008 | PubMed
  146. A human breast cell model of preinvasive to invasive transition.
    2008 | PubMed
  147. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.
    2008 | PubMed
  148. Integrin-mediated signalling through the MAP-kinase pathway.
    2008 | PubMed
  149. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures.
    2008 | PubMed
  150. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.
    2007 | PubMed
  151. G'rab'bing the microenvironment for invasion.
    2007 | PubMed
  152. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.
    2007 | PubMed
  153. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis.
    2007 | PubMed
  154. The ultrastructure of MCF-10A acini.
    2006 | PubMed
  155. Forcing the third dimension.
    2006 | PubMed
  156. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard.
    2005 | PubMed
  157. Tensional homeostasis and the malignant phenotype.
    2005 | PubMed
  158. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.
    2005 | PubMed
  159. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression.
    2005 | PubMed
  160. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.
    2005 | PubMed
  161. The tension mounts: mechanics meets morphogenesis and malignancy.
    2004 | PubMed
  162. Watch thy neighbor: cancer is a communal affair.
    2004 | PubMed
  163. Death in the third dimension: apoptosis regulation and tissue architecture.
    2004 | PubMed
  164. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.
    2003 | PubMed
  165. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.
    2003 | PubMed
  166. The tissue microenvironment as an epigenetic tumor modifier.
    2003 | PubMed
  167. The organizing principle: microenvironmental influences in the normal and malignant breast.
    2002 | PubMed
  168. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.
    2002 | PubMed
  169. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?
    2002 | PubMed
  170. Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.
    2001 | PubMed
  171. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods.
    2000 | PubMed
  172. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture.
    1999 | PubMed
  173. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3.
    1999 | PubMed
  174. Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells.
    1999 | PubMed
  175. Tissue structure, nuclear organization, and gene expression in normal and malignant breast.
    1999 | PubMed
  176. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.
    1998 | PubMed
  177. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus.
    1998 | PubMed
  178. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.
    1998 | PubMed
  179. Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.
    1998 | PubMed
  180. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.
    1997 | PubMed
  181. Extracellular matrix: the central regulator of cell and tissue homeostasis.
    1997 | PubMed
  182. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.
    1996 | PubMed
  183. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.
    1996 | PubMed
  184. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay.
    1996 | PubMed
  185. The development of a functionally relevant cell culture model of progressive human breast cancer.
    1995 | PubMed
  186. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes.
    1993 | PubMed