News & Events
Displaying 1 - 12 of 12
Displaying 1 - 12 of 12
Dr. Valerie Weaver Receives NCI Outstanding Investigator Award (OIA) and $6.7M R35 Grant
UCSF Department of Surgery
September 23, 2020
Valerie Weaver, Ph.D., Professor of Surgery in the Departments of Surgery, Anatomy, and Bioengineering & Therapeutics Sciences, and Director of the Center for Bioengineering & Tissue Regeneration, is the recipient of a National Cancer Institute (NCI) Outstanding Investigator Award (OIA) (R35), supporting a 7-year...
The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate
UCSF Department of Surgery
May 29, 2018
Read our new chapter in Current Topics in Developmental Biology. https://authors.elsevier.com/b/1X7ThFzn76kQw
Super-resolution imaging platform published in Integrative Biology
UCSF Department of Surgery
June 23, 2016
Congratulations to Guanqing Ou and coauthors on their publication in Integrative Biology! Abstract: The mechanical properties of the extracellular matrix influence cell signaling to regulate key cellular processes, including differentiation, apoptosis, and transformation. Understanding the molecular mechanisms...
Study on pancreatic cancer published in Nature Medicine
UCSF Department of Surgery
April 19, 2016
Congratulations to Hanane Laklai and coauthors on their publication in Nature Medicine! Abstract: Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality, yet antistromal therapies are controversial. We found that human PDACs with impaired epithelial transforming...
UCSF News
April 18, 2016
UCSF news recently highlighted our publication in Nature Medicine: Gene Mutation Makes Tumors Tense, Worsens Patient Prognosis Special Treatment For Patients With “Schwarzenegger” Tumors May Improve Outcomes By Nicholas Weiler on April 18, 2016 UC San Francisco researchers have discovered that the chances of...
Dr. Weaver featured in Faculty Perspective
UCSF Department of Surgery
February 17, 2016
Dr. Weaver was interviewed in depth by the Bioengineering Department and featured in a Faculty Perspective in BioE News: A conversation with Professor Valerie Weaver, UCSF Professor of Surgery, about work in her highly collaborative cancer research lab. What is the main focus of your lab? We do a lot of work on...
Methods paper on traction force microscopy in developing embryos published
UCSF Department of Surgery
February 03, 2016
Congratulations to Laralynne Przybyla and coauthors on their publication in Methods! Abstract: The way cells are organized within a tissue dictates how they sense and respond to extracellular signals, as cues are received and interpreted based on expression and organization of receptors, downstream signaling...
Mechanical Forces Driving Breast Cancer Lead to Key Molecular Discovery
UCSF Department of Surgery
March 27, 2014
"The stiffening of breast tissue in breast-cancer development points to a new way to distinguish a type of breast cancer with a poor prognosis from a related, but often less deadly type, UC San Francisco researchers have found in a new study. The findings, published online March 16 in Nature Medicine , may lead...
The Center for Bioengineering and Tissue Regeneration Opens A Newly Renovated Laboratory
UCSF Department of Surgery
October 21, 2010
The UCSF Center for Bioengineering and Tissue Regeneration, led by Valerie Weaver, PhD, Professor of Surgery, moves into newly renovated lab space. This new, fully equipped lab facility provides an ideal environment for UCSF researchers to carry out the center's initiative to better understand cancer and therefore...
UCSF researchers identify gene involved in inhibiting breast tumor growth
UCSF Department of Surgery
April 14, 2010
Valerie Weaver and collaborators have identified the first positive regulator of BRCA1, establishing that the loss of the homeobox gene HoxA9 promotes tumor growth in breasts. The scientists found that restoring HoxA9 in breast cancer cells inhibited their malignant behavior in culture and in vivo. Intriguingly...
Cell Article Discusses The Role of Matrix Crosslinking in Tumor Progression by Enhancing Integrin Signaling
UCSF Department of Surgery
March 03, 2010
Weaver and colleagues showed that collagen crosslinking drives tumor progression. The report established a correlation between collagen crosslinking and extracellular matrix (ECM) stiffness in mouse models and implicates the ECM-crosslinking enzyme lysyl oxidase (LOX) as a culprit driving stiffness-associated...
NIH Awards Valerie Weaver and Group Virtual Physical Sciences / Oncology Center Grant
UCSF Department of Surgery
September 15, 2009
The National Institutes of Health awarded Valerie Weaver, PhD, Director of the UCSF Center for Bioengineering and Tissue Regeneration and her colleagues a grant for the establishment of a virtual Physical Sciences - Oncology Center for the development of novel approaches to cancer diagnostics, prognosis and...